SCHEMBL21113564

SCHEMBL21113564

Cn1c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21.NC1=NC(=O)C2=NC(=O)N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=N1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.54
▸ KMT2A Q03164 2/20 0.54
▸ TLR7 Q9NYK1 2/20 0.53
▸ PNP P00491 3/20 0.51
▸ CYP3A4 P08684 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ CYP1A2 P05177 1/20 0.36
▸ HSPA5 P11021 1/20 0.34
▸ HSPA8 P11142 1/20 0.34
▸ GMNN O75496 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ NFKB1 P19838 1/20 0.34
▸ DNMT1 P26358 1/20 0.34
▸ THPO P40225 1/20 0.34
▸ MTOR P42345 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ BLM P54132 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26079955 0.85 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL23202083 0.85 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL10117778 0.85 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL455853 0.85 MEN1 (0.71) MEN1KMT2ATLR7PNPCYP3A4
SCHEMBL114650 0.80 LMNA (0.45) PNPMAPTGMNNALDH1A1LMNA
SCHEMBL6448926 0.77 PNP (0.66) MEN1KMT2ATLR7PNPCYP3A4
Phosphoric Acid SCHEMBL20305093 0.77 LMNA (0.42) PNPMAPTGMNNALDH1A1LMNA
SCHEMBL28692399 0.77 MEN1 (0.72) MEN1KMT2ATLR7PNPCYP3A4
Phosphoric Acid SCHEMBL6465085 0.77 LMNA (0.42) PNPMAPTGMNNALDH1A1LMNA
Deoxyguanosine SCHEMBL29106456 0.75 POLB (0.51) PNPLMNATP53DNMT1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866754-B2 Trinucleotide mRNA cap analogs MODERNATX, INC. (US) 2024-01-09 — — US disclosed
US-20190211368-A1 TRINUCLEOTIDE MRNA CAP ANALOGS MODERNATX, INC. 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190211368-A1 TRINUCLEOTIDE MRNA CAP ANALOGS RNGTT, RNMT, CPSF7 MEN1 4726/4885KMT2A 2782/4885TLR7 2428/4885
US-11866754-B2 Trinucleotide mRNA cap analogs RNGTT, RNMT, CPSF7 MEN1 4726/4885KMT2A 2782/4885TLR7 2428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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