Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PON1 | P27169 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434378 | 0.84 | P2RX7 (0.35) | PON1P2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL21577569 | 0.81 | P2RX7 (0.33) | P2RX7 | |
| SCHEMBL31414091 | 0.78 | — | — | |
| SCHEMBL2495516 | 0.78 | PON1 (0.43) | PON1 | |
| SCHEMBL1019627 | 0.77 | PON1 (0.35) | PON1 | |
| Ammonia Solution, Strong SCHEMBL136349 | 0.76 | PON1 (0.46) | PON1 | |
| Phosphine SCHEMBL15203731 | 0.76 | PON1 (0.42) | PON1 | |
| SCHEMBL1337533 | 0.74 | PON1 (0.37) | PON1 | |
| SCHEMBL8343195 | 0.73 | MPO (0.38) | P2RX7 | |
| SCHEMBL14989943 | 0.73 | RIPK1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541811-B | Pyrazolopyrimidine Derivatives | DAIICHI SANKYO CO LTD | 2014-07-09 | — | — | CN | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| CN-101541811-A | Pyrazolopyrimidine Derivatives | DAIICHI SANKYO CO LTD (JP) | 2009-09-23 | — | — | CN | disclosed |
| EP-2065388-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | HSP90AB1, HSP90B1, HSP90AA1 | PON1 2766/4885P2RX7 2142/4885HTR2A 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.