SCHEMBL21117299

SCHEMBL21117299

N#Cc1cc(-c2nnc(NC3N=C(c4ccccc4)C4=CCCC=C4NC3=O)o2)ccc1F

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 5/20 0.37
FPR1 P21462 2/20 0.37
PGR P06401 1/20 0.33
CDC7 O00311 1/20 0.32
CCNE1 P24864 1/20 0.32
CDK2 P24941 1/20 0.32
DBF4 Q9UBU7 1/20 0.32
FLT3 P36888 1/20 0.32
CCKBR P32239 1/20 0.31
ROCK2 O75116 1/20 0.31
LRRK2 Q5S007 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
GSK3B P49841 1/20 0.30
AR P10275 1/20 0.30
ADCY8 P40145 1/20 0.30
ADCY1 Q08828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21117290 0.84 FPR2 (0.38) FPR2FPR1CDC7CCNE1CDK2
SCHEMBL21755278 0.83 CCKBR (0.47) CCKBR
SCHEMBL20098195 0.83 CCKBR (0.47) CCKBR
SCHEMBL21755220 0.77 CCKBR (0.48) CCKBR
SCHEMBL20098399 0.77 CCKBR (0.48) CCKBR
SCHEMBL21117152 0.75 CCKBR (0.34) CCKBR
SCHEMBL20098088 0.72 CCKBR (0.48) CCKBR
SCHEMBL21755231 0.72 CCKBR (0.48) CCKBR
SCHEMBL21117554 0.71 TUBB4A (0.35) CCKBR
SCHEMBL20098363 0.69 CCKBR (0.44) FPR2FPR1CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-01-05 US disclosed
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors SERPINB1, FURIN, HIF1AN FPR2 154/4885FPR1 72/4885PGR 4188/4885
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN FPR2 154/4885FPR1 72/4885PGR 4188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.