Sugi Predict

Sugi Predict / Compounds / SCHEMBL2111803

SCHEMBL2111803

SCHEMBL2111803

NC(c1ccccc1)c1ccccn1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 P23975 2/20 0.63
▸ SLC6A4 P31645 2/20 0.63
▸ SLC6A3 Q01959 1/20 0.63
▸ GRIN2D O15399 1/20 0.48
▸ GRIN3B O60391 1/20 0.48
▸ GRIN1 Q05586 1/20 0.48
▸ GRIN2A Q12879 1/20 0.48
▸ GRIN2B Q13224 1/20 0.48
▸ GRIN2C Q14957 1/20 0.48
▸ GRIN3A Q8TCU5 1/20 0.48
▸ CHRM2 P08172 1/20 0.47
▸ SCN1A P35498 1/20 0.47
▸ SCN2A Q99250 1/20 0.47
▸ SCN3A Q9NY46 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.44
▸ DPP4 P27487 2/20 0.42
▸ F2 P00734 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6766141 1.00 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL3384423 1.00 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL1421214 0.98 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL7226415 0.98 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL4509965 0.98 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL589267 0.93 SLC6A3 (0.54) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL17842115 0.88 SLC6A2 (0.48) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL1131039 0.86 SLC6A2 (0.54) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL6776456 0.84 SLC6A3 (0.46) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B
SCHEMBL6775380 0.84 SLC6A3 (0.46) SLC6A2SLC6A4SLC6A3GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6657065-B2 Which are useful as microsomal triglyceride transfer protein (MTP) inhibitors PFIZER INC 2003-12-02 — — US claimed
US-20020161233-A1 Methods of making quinoline amides TOM NORMA J (US) 2002-10-31 — — US claimed
US-20020132806-A1 7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B RUGGERI ROGER (US) 2002-09-19 — — US claimed
US-20020042516-A1 Methods of making quinoline amides TOM NORMA J (US) 2002-04-11 — — US claimed
US-6369075-B1 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B PFIZER, INC. 2002-04-09 — — US claimed
EP-1099701-A1 7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B Pfizer Products Inc. (US) 2001-05-16 — — EP claimed
CN-117756781-B Indole histone deacetylase family inhibitor with anti-tumor effect 沈阳药科大学 2025-06-13 — — CN disclosed
CN-117756781-A Indole histone deacetylase family inhibitor with anti-tumor effect 沈阳药科大学 2024-03-26 — — CN disclosed
WO-2023250439-A1 TREX1 INHIBITORS AND USES THEREOF TEMPEST THERAPEUTICS, INC. (US) 2023-12-28 — — WO disclosed
CN-116751198-A Preparation method of imidazo six-membered aza compound containing isothiourea fragment 上海工程技术大学 2023-09-15 — — CN disclosed
WO-2023109254-A1 METHOD FOR ONE-STEP DIRECT PREPARATION OF 3-ACYL IMIDAZO[1,5-A]PYRIDINE BY MEANS OF [4+1] DUAL AMINATION REACTIONS OF KETOMETHYL 安徽科技学院 2023-06-22 — — WO disclosed
US-11459308-B2 Broad spectrum inhibitors of filoviruses MICROBIOTIX, INC. (US) 2022-10-04 — — US disclosed
US-20220289728-A1 MODULATORS OF TREX1 CONSTELLATION PHARMACEUTICALS INC (US) 2022-09-15 — — US disclosed
EP-0240050-B1 A METHOD FOR CONTROLLING WEEDS JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-26 — — EP disclosed
EP-0415413-A1 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-03-06 — — EP disclosed
US-4770689-A TRANSPLANTED RICE AND MAIZE CROPS JANSSEN PHARMACEUTICA N.V. (BE) 1988-09-13 — — US disclosed
EP-0240050-A1 A method for controlling weeds JANSSEN PHARMACEUTICA N.V. (BE) 1987-10-07 — — EP disclosed
CN-87101880-A METHOD FOR CONTROLLING WEEDS — 1987-09-23 — — CN disclosed
US-4006239-A Benzoic acid amides for mycobacterium infections BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 — — US disclosed
US-3995044-A Pyridine carboxylic acid amides for mycobacterium infections BAYER AKTIENGESELLSCHAFT (DT) 1976-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020161233-A1 Methods of making quinoline amides CETP, MTTP, LCAT SLC6A2 501/4885SLC6A4 954/4885SLC6A3 1239/4885
US-20020042516-A1 Methods of making quinoline amides CETP, MTTP, LCAT SLC6A2 501/4885SLC6A4 954/4885SLC6A3 1239/4885
US-11459308-B2 Broad spectrum inhibitors of filoviruses NPC1L1, NPC1, GBA1 SLC6A2 2661/4885SLC6A4 3095/4885SLC6A3 2256/4885
US-20220289728-A1 MODULATORS OF TREX1 CFTR, SLC10A1, CYP27A1 SLC6A2 1249/4885SLC6A4 1663/4885SLC6A3 1864/4885
US-20020132806-A1 7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B APOB, CETP, PNLIP SLC6A2 2815/4885SLC6A4 3934/4885SLC6A3 3302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.