Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4613870 | 0.88 | LMNA (0.57) | LMNAGAAKMT2ATTRALDH1A1 | |
| SCHEMBL18570579 | 0.86 | L3MBTL1 (0.46) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL22809589 | 0.85 | SLC6A4 (0.56) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL18570517 | 0.85 | L3MBTL1 (0.62) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19563652 | 0.85 | HTR2A (0.51) | LMNAKMT2ATTRALDH1A1CYP1A2 | |
| SCHEMBL19563647 | 0.85 | SCN8A (0.46) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL3484746 | 0.83 | L3MBTL1 (0.39) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL19563654 | 0.82 | SCN8A (0.47) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL22809585 | 0.81 | SCN8A (0.48) | LMNAL3MBTL1SCN8ASCN10AMAPT | |
| SCHEMBL19524164 | 0.81 | MAPT (0.65) | LMNACYP1A2CYP2C9CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2951155-B1 | AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2019-06-19 | — | — | EP | disclosed |
| US-6506775-B1 | Treatment of a gastrointestinal disorder; a central nervous system (CNS) adverse conditions caused by Heliobacter pylori; or angiogenesis especially CNS disorders in a mammalian subject, especially humans. | PFIZER INC | 2003-01-14 | — | — | US | disclosed |
| US-6329396-B1 | TREATMENT OF GASTROINTESTINAL DISORDERS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; INFLAMMATORY DISEASE; EMESIS; URINARY INCONTINENCE; PAIN; MIGRAINE; SUNBURN; DISEASES, DISORDERS AND ADVERSE CONDITIONS CAUSED BY HELIOBACTER PYLORI; OR | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1114817-A1 | Substituted benzylamino piperidine compounds | PFIZER INC. (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0861235-A1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER INC. (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997008144-A1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER PHARMACEUTICALS INC. (JP) | 1997-03-06 | — | — | WO | disclosed |