Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26342338 | 0.75 | SMN1; SMN2 (0.40) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL20194036 | 0.74 | — | — | |
| SCHEMBL19035678 | 0.69 | ALDH1A1 (0.35) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL21842697 | 0.65 | GAA (0.40) | ALDH1A1SMN1; SMN2ITGB1ITGA4KDM4E | |
| SCHEMBL791197 | 0.64 | — | — | |
| SCHEMBL3262475 | 0.62 | L3MBTL1 (0.44) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL28647773 | 0.62 | ALDH1A1 (0.44) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL2965438 | 0.61 | ALDH1A1 (0.45) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL725861 | 0.61 | ALDH1A1 (0.49) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL21814504 | 0.61 | ALDH1A1 (0.48) | ALDH1A1CYP3A4L3MBTL1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190202855-A1 | POLYNUCLEOTIDE CONSTRUCTS | SIRIUS THERAPEUTICS, INC. | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202855-A1 | POLYNUCLEOTIDE CONSTRUCTS | PHAX, CPSF6, RNGTT | ALDH1A1 3953/4885CYP3A4 4813/4885L3MBTL1 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.