Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | PI4KA | P42356 | 4/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21057417 | 0.81 | KMO (0.33) | TDO2TP53MAPK1ALDH1A1 | |
| SCHEMBL19917015 | 0.73 | FFAR2 (0.39) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21159362 | 0.62 | EGFR (0.42) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL19917018 | 0.62 | EGFR (0.42) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL19917175 | 0.61 | PDE5A (0.35) | TDO2TP53MAPK1MEN1ALDH1A1 | |
| SCHEMBL17603703 | 0.60 | NPC1 (0.33) | — | |
| SCHEMBL22716378 | 0.59 | ADORA2A (0.38) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL14379265 | 0.59 | DGAT1 (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL18977643 | 0.59 | POLB (0.50) | TDO2PDE8BCYP2C9HSD17B10MEN1 | |
| SCHEMBL16075033 | 0.58 | RET (0.38) | ADORA2API4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | PDE7B, PDE3A, PDE7A | ADORA2A 1642/4885PI4KA 1612/4885PI4K2B 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.