Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL231675 | 0.85 | ALDH1A1 (0.48) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL485968 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL28502490 | 0.82 | ALDH1A1 (0.49) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| Bromide SCHEMBL29044663 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| Bromide SCHEMBL3290361 | 0.82 | ALDH1A1 (0.55) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| Bromide SCHEMBL29669478 | 0.81 | DNM1 (0.51) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| Bromide SCHEMBL19971582 | 0.81 | DNM1 (0.57) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| Bromide SCHEMBL231434 | 0.81 | DNM1 (0.59) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL16731588 | 0.81 | DNM1 (0.51) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL14130437 | 0.80 | ALDH1A1 (0.48) | ALDH1A1SRD5A2L3MBTL1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8679454-B2 | Particle immobilized coatings and uses thereof | SURMODICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8158106-B2 | Drug delivery; microparticles immobilized on polymer surface | SURMODICS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| EP-1432989-B1 | RANDOMLY ORDERED ARRAYS AND METHODS OF MAKING AND USING | SURMODICS INC (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20090186070-A1 | Particle immobilized coating and uses thereof | Surmodics Coatings, LLC | 2009-07-23 | — | — | US | disclosed |
| US-20080039343-A1 | Randomly Ordered Arrays and Methods of Making and Using | SURMODICS, INC. (US) | 2008-02-14 | — | — | US | disclosed |
| US-7195913-B2 | Randomly ordered arrays and methods of making and using | SURMODICS, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1434571-B1 | PARTICLE IMMOBILIZED COATINGS AND USES THEREOF | SURMODICS INC (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1444034-A2 | ARRAYS HAVING CLUSTERED ARRANGEMENTS AND METHODS OF MAKING AND USING THEM | SurModics, Inc. (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1434571-A1 | PARTICLE IMMOBILIZED COATINGS AND USES THEREOF | SurModics, Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1432989-A1 | RANDOMLY ORDERED ARRAYS AND METHODS OF MAKING AND USING | SurModics, Inc. (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20030129130-A1 | Particle immobilized coatings and uses thereof | SURMODICS, INC. | 2003-07-10 | — | — | US | disclosed |
| US-20030099949-A1 | Arrays having clustered arrangements and methods of making and using | SURMODICS, INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2003030879-A1 | PARTICLE IMMOBILIZED COATINGS AND USES THEREOF | SURMODICS, INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| WO-2003031979-A1 | RANDOMLY ORDERED ARRAYS AND METHODS OF MAKING AND USING | SURMODICS, INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| WO-2003031054-A2 | ARRAYS HAVING CLUSTERED ARRANGEMENTS AND METHODS OF MAKING AND USING THEM | SURMODICS, INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| US-20030073086-A1 | Randomly ordered arrays and methods of making and using | SURMODICS, INC. | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186070-A1 | Particle immobilized coating and uses thereof | SELP, SELPLG, PLAUR | ACHE 2810/4885ALDH1A1 1797/4885SRD5A2 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.