Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.37 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529487 | 0.83 | IDO1 (0.54) | IDO1FFAR1CYP11B2GFRA2GFRA3 | |
| SCHEMBL12017975 | 0.82 | IDO1 (0.61) | IDO1FFAR1DDB1CRBNCYP11B2 | |
| SCHEMBL21142124 | 0.80 | IDO1 (0.54) | IDO1FFAR1CYP11B2GFRA2GFRA3 | |
| SCHEMBL12320928 | 0.80 | IDO1 (0.54) | IDO1FFAR1DDB1CRBNCYP11B2 | |
| SCHEMBL12320501 | 0.79 | IDO1 (0.50) | IDO1FFAR1 | |
| SCHEMBL1746407 | 0.77 | FFAR1 (0.60) | IDO1FFAR1 | |
| SCHEMBL12320190 | 0.76 | FFAR1 (0.52) | IDO1FFAR1DDB1CRBNCYP11B2 | |
| SCHEMBL1746615 | 0.74 | FFAR1 (0.60) | IDO1FFAR1GFRA2GFRA3 | |
| SCHEMBL8530467 | 0.73 | IDO1 (0.50) | IDO1FFAR1GFRA2GFRA3 | |
| SCHEMBL1745291 | 0.72 | MAPK1 (0.63) | IDO1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2887964-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2019-07-03 | — | — | EP | disclosed |