Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.52 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.39 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12017975 | 0.86 | IDO1 (0.61) | IDO1FFAR1PDPK1CYP11B2GFRA2 | |
| SCHEMBL12320928 | 0.83 | IDO1 (0.54) | IDO1FFAR1PRCPPDPK1CYP11B2 | |
| SCHEMBL8529487 | 0.83 | IDO1 (0.54) | IDO1FFAR1PDPK1CYP11B2GFRA2 | |
| SCHEMBL21527129 | 0.83 | SLC6A2 (0.42) | FFAR1PRCPSLC6A2SLC6A4CYP2D6 | |
| SCHEMBL9797336 | 0.80 | HTR2C (0.53) | IDO1FFAR1PRCPGID4 | |
| SCHEMBL21142126 | 0.80 | IDO1 (0.50) | IDO1FFAR1PDPK1CYP11B2GFRA2 | |
| SCHEMBL12320190 | 0.80 | FFAR1 (0.52) | IDO1FFAR1PDPK1CYP11B2GFRA2 | |
| SCHEMBL12320501 | 0.80 | IDO1 (0.50) | IDO1FFAR1 | |
| SCHEMBL9797385 | 0.79 | SIGMAR1 (0.43) | PRCP | |
| Bromide SCHEMBL9797412 | 0.78 | SIGMAR1 (0.42) | PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2887964-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2019-07-03 | — | — | EP | disclosed |