Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | TYMS | P04818 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16440333 | 0.76 | ERN1 (0.41) | BACE1TYMSPIM3ALDH1A1ERN1 | |
| SCHEMBL17973095 | 0.76 | TYMS (0.54) | BACE1TYMSPIM3ALDH1A1ERN1 | |
| SCHEMBL15042999 | 0.73 | LMNA (0.42) | BACE1TYMSPIM3ALDH1A1ERN1 | |
| SCHEMBL29959587 | 0.72 | PTGES (0.51) | ALDH1A1PTGESRAB9AMMP2MMP9 | |
| SCHEMBL26693457 | 0.72 | PTGES (0.51) | ALDH1A1PTGESRAB9AMMP2MMP9 | |
| SCHEMBL12294884 | 0.69 | LMNA (0.36) | BACE1TYMSPIM3ALDH1A1PTGES | |
| SCHEMBL13560994 | 0.69 | LMNA (0.36) | BACE1TYMSPIM3ALDH1A1PTGES | |
| SCHEMBL12294840 | 0.69 | LMNA (0.36) | BACE1TYMSPIM3ALDH1A1PTGES | |
| SCHEMBL14758479 | 0.66 | CDC7 (0.48) | BACE1PIM1CYP1A2 | |
| SCHEMBL56836 | 0.65 | CYP2A6 (0.57) | BACE1ALDH1A1ERN1CYP2A6PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344019-B2 | Antiviral compounds | GILEAD PHARMASSET LLC (US) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344019-B2 | Antiviral compounds | MAVS, EIF2AK2, ZC3HAV1 | BACE1 3126/4885TYMS 118/4885PIM3 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.