Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | PLK1 | P53350 | 9/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.40 |
| ▸ | KIT | P10721 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116812 | 0.97 | PLK1 (0.43) | PIK3CGPIK3CAPIK3CBPLK1PDGFRB | |
| SCHEMBL2114106 | 0.92 | PIK3CG (0.43) | PIK3CGPIK3CAPIK3CBPLK1PDGFRB | |
| SCHEMBL2113545 | 0.91 | PLK1 (0.46) | PLK1PDGFRBKDRPLK3KIT | |
| SCHEMBL2112977 | 0.88 | PLK1 (0.49) | PLK1PDGFRBKDRPLK3KIT | |
| SCHEMBL2113295 | 0.87 | IGF1R (0.43) | PLK1NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL2115008 | 0.84 | HRH3 (0.46) | PLK1PDGFRBKDRPLK3 | |
| SCHEMBL2116827 | 0.83 | KDR (0.44) | PLK1PDGFRBKDRPLK3KIT | |
| SCHEMBL2113595 | 0.83 | IGF1R (0.44) | PLK1PDGFRBKDRPLK3KIT | |
| SCHEMBL2113363 | 0.83 | LMNA (0.47) | PLK1KDRFGFR1 | |
| SCHEMBL4199140 | 0.82 | KDM4E (0.41) | PIK3CGPIK3CAPIK3CBCCR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158641-B2 | 2-anilino-4-aminoalkyleneaminopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20090181995-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-16 | — | — | US | disclosed |
| US-20070293525-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293525-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | PRKCA, PRKCH, PRKCG | PIK3CG 137/4885PIK3CA 293/4885PIK3CB 175/4885 |
| US-20090181995-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | PRKCA, PRKCH, PRKCG | PIK3CG 137/4885PIK3CA 293/4885PIK3CB 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.