Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | PLK1 | P53350 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.44 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112977 | 0.93 | PLK1 (0.49) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2113545 | 0.92 | PLK1 (0.46) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2114106 | 0.91 | PIK3CG (0.43) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2115650 | 0.86 | IGF1R (0.46) | KDRDHFRHDAC3HDAC1HDAC2 | |
| SCHEMBL5525215 | 0.84 | DHFR (0.39) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2116812 | 0.84 | PLK1 (0.43) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2115039 | 0.83 | PIK3CG (0.40) | KDRPDGFRBPLK1FGFR1FLT3 | |
| SCHEMBL2114807 | 0.81 | LMNA (0.50) | KDRALKCSF1RIGF1RTNK2 | |
| SCHEMBL2113337 | 0.80 | TNK2 (0.44) | KDRHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2114730 | 0.79 | DHFR (0.42) | KDRPDGFRBPLK1PLK3DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158641-B2 | 2-anilino-4-aminoalkyleneaminopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20090181995-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-16 | — | — | US | disclosed |
| US-20070293525-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293525-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | PRKCA, PRKCH, PRKCG | KDR 2773/4885PDGFRB 796/4885PLK1 644/4885 |
| US-20090181995-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | PRKCA, PRKCH, PRKCG | KDR 2773/4885PDGFRB 796/4885PLK1 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.