Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18065823 | 1.00 | HSD17B10 (0.43) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL14045138 | 0.86 | FKBP1A (0.45) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL196944 | 0.86 | FKBP1A (0.45) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL7256996 | 0.85 | HSD17B10 (0.43) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL16000757 | 0.85 | DPP4 (0.46) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL6783598 | 0.85 | HSD17B10 (0.43) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL7256995 | 0.85 | HSD17B10 (0.43) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL196943 | 0.85 | HSD17B10 (0.43) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL6782774 | 0.84 | ACE (0.44) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 | |
| SCHEMBL6782779 | 0.84 | ACE (0.44) | HSD17B10KLK5FKBP1ASMN1; SMN2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10118927-B2 | Substituted piperidin-4-amino-type compounds and uses thereof | PURDUE PHARMA L.P. (US) | 2018-11-06 | — | — | US | disclosed |
| US-20160272640-A1 | SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2016-09-22 | — | — | US | disclosed |
| US-20160272640-A1 | SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2016-09-22 | — | — | US | disclosed |
| US-20160272640-A1 | SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2016-09-22 | — | — | US | disclosed |
| WO-2014102590-A1 | SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF | PURDUE PHARMA L.P. (US) | 2014-07-03 | — | — | WO | disclosed |
| US-20120095003-A1 | METHODS OF USING PRODRUGS OF METHYL HYDROGEN FUMARATE AND PHARMACEUTICAL COMPOSITIONS THEREOF | XENOPORT, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8148414-B2 | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use | XENOPORT, INC. (US) | 2012-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095003-A1 | METHODS OF USING PRODRUGS OF METHYL HYDROGEN FUMARATE AND PHARMACEUTICAL COMPOSITIONS THEREOF | FH, MGMT, BHMT2 | HSD17B10 470/4885KLK5 1977/4885FKBP1A 596/4885 |
| US-20160272640-A1 | SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF | OPRD1, OPRL1, P2RX4 | HSD17B10 4470/4885KLK5 4288/4885FKBP1A 4157/4885 |
| US-10118927-B2 | Substituted piperidin-4-amino-type compounds and uses thereof | OPRD1, OPRL1, P2RX4 | HSD17B10 4470/4885KLK5 4288/4885FKBP1A 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.