Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610203 | 1.00 | CHRM1 (0.52) | CHRM1CHRM2CHRM4KMT2ALMNA | |
| SCHEMBL2113907 | 0.93 | CHRM1 (0.54) | CHRM1CHRM2CHRM4KMT2ALMNA | |
| SCHEMBL2610210 | 0.80 | CTSS (0.49) | CHRM1CHRM2CHRM4KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2113656 | 0.79 | CTSS (0.48) | CHRM1CHRM2CHRM4KMT2AMEN1 | |
| SCHEMBL2113085 | 0.79 | CHRM1 (0.45) | CHRM1CHRM2CHRM4LMNANPC1 | |
| SCHEMBL2610204 | 0.79 | CHRM1 (0.45) | CHRM1CHRM2CHRM4LMNANPC1 | |
| SCHEMBL2726067 | 0.77 | CTSS (0.69) | CHRM1CHRM2CHRM4KMT2AMEN1 | |
| SCHEMBL2113830 | 0.77 | CTSS (0.69) | CHRM1CHRM2CHRM4KMT2AMEN1 | |
| SCHEMBL2726066 | 0.77 | CTSS (0.69) | CHRM1CHRM2CHRM4KMT2AMEN1 | |
| SCHEMBL2114479 | 0.76 | DGAT2 (0.47) | CHRM1CHRM2CHRM4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227468-B2 | Cathepsin S inhibitor compounds | ELI LILLY AND COMPANY (US) | 2012-07-24 | — | — | US | disclosed |
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | ELI LILLY AND COMPANY (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | CTSS, CTSZ, CTSV | CHRM1 4241/4885CHRM2 4275/4885CHRM4 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.