SCHEMBL21153364

SCHEMBL21153364

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nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MMP3 P08254 8/20 0.49
▸ MMP9 P14780 4/20 0.42
▸ MME P08473 4/20 0.42
▸ ALDH1A1 P00352 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ANPEP P15144 1/20 0.37
▸ MAPT P10636 1/20 0.36
▸ BIRC2 Q13490 1/20 0.35
▸ FOLH1 Q04609 2/20 0.34
▸ MMP2 P08253 1/20 0.34
▸ MMP8 P22894 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27325467 0.82 MMP3 (0.44) MMP3MMP9ALDH1A1MEN1LMNA
SCHEMBL21153561 0.82 MME (0.43) MMP3MMP9MMEALDH1A1MEN1
SCHEMBL20021565 0.79 ALDH1A1 (0.45) MMP9MMEALDH1A1MEN1LMNA
SCHEMBL29311779 0.73 MME (0.37) MMP3MME
SCHEMBL7027957 0.73 MME (0.41) MMEALDH1A1MMP8
SCHEMBL12537181 0.71 ALDH1A1 (0.67) MMP9ALDH1A1MEN1LMNAKMT2A
SCHEMBL18456748 0.70 MMP3 (0.33) MMP3ALDH1A1FOLH1MMP2
SCHEMBL16508503 0.70 MME (0.44) MMP9MMEALDH1A1MEN1LMNA
SCHEMBL20756785 0.70 MMP3 (0.51) MMP3MMP9ALDH1A1MEN1LMNA
SCHEMBL19371329 0.70 MMP3 (0.33) MMP3MMP9FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240067640-A1 PHENYL MALEIMIDE LINKER AGENTS FIREFLY BIO, INC. 2024-02-29 — — US disclosed
US-20190209702-A1 STEROIDS AND ANTIBODY-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190209702-A1 STEROIDS AND ANTIBODY-CONJUGATES THEREOF SERPINA6, NR3C1, NR3C2 MMP3 2441/4885MMP9 4068/4885MME 1994/4885
US-20240067640-A1 PHENYL MALEIMIDE LINKER AGENTS TPX2, H1-4, MAPT MMP3 3026/4885MMP9 4214/4885MME 1004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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