SCHEMBL21153740

SCHEMBL21153740

CCCc1coc(Cc2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.50
DAO P14920 1/20 0.38
CALM1 P0DP23 1/20 0.38
TP53 P04637 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
POLB P06746 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ALOX5 P09917 1/20 0.35
ATM Q13315 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
KIF11 P52732 1/20 0.34
TDP1 Q9NUW8 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
BCL2 P10415 1/20 0.33
BCL2L1 Q07817 1/20 0.33
TRPC5 Q9UL62 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15978541 0.85 IDH1 (0.53) IDH1DAOCALM1TP53BCL2
SCHEMBL27719076 0.83 IDH1 (0.58) IDH1DAOCALM1SMN1; SMN2RAB9A
SCHEMBL8977412 0.82 IDH1 (0.54) IDH1DAOCALM1TDP1BCL2
SCHEMBL11173312 0.78 IDH1 (0.53) IDH1DAOCALM1SMN1; SMN2NPC1
SCHEMBL11195540 0.78 IDH1 (0.53) IDH1DAOCALM1SMN1; SMN2RAB9A
SCHEMBL11483794 0.78 IDH1 (0.57) IDH1DAOCALM1POLBBCL2
SCHEMBL358651 0.78 IDH1 (0.57) IDH1DAOCALM1ALOX5TDP1
SCHEMBL15977315 0.77 IDH1 (0.49) IDH1DAOCALM1SMN1; SMN2NPC1
SCHEMBL9559052 0.77 L3MBTL1 (0.46) IDH1SMN1; SMN2NPC1RAB9AALOX5
SCHEMBL584803 0.76 IDH1 (0.54) IDH1DAOCALM1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11008596-B2 Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2021-05-18 US disclosed
US-20190211367-A1 VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2019-07-11 US disclosed