Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157655 | 0.80 | MAPT (0.55) | APLNRMAPTHTR2AHTR2CALDH1A1 | |
| SCHEMBL20912632 | 0.74 | MAPT (0.55) | APLNRMAPTALDH1A1POLBTDP1 | |
| SCHEMBL523291 | 0.74 | APLNR (0.63) | APLNRMAPTHTR2AHTR2CHDAC3 | |
| SCHEMBL21154838 | 0.73 | CYP4F2 (0.44) | MAPTKMT2AALDH1A1NPSR1TSHR | |
| SCHEMBL23635828 | 0.73 | HPGD (0.56) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL12093644 | 0.73 | KDM4E (0.56) | MAPTALDH1A1NPSR1RAB9ATSHR | |
| SCHEMBL783785 | 0.72 | APLNR (1.00) | APLNRHTR2AHTR2CHDAC3HDAC1 | |
| SCHEMBL2225000 | 0.72 | APLNR (0.60) | APLNRMAPTHTR2AHTR2CHDAC3 | |
| SCHEMBL22852762 | 0.71 | HPGD (0.57) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL7488349 | 0.71 | KMT2A (0.67) | HDAC3HDAC1HDAC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134680-A1 | INHIBITOR OF APOPTOSIS SIGNAL-REGULATING KINASE-1 AND APPLICATION THEREOF | 广州市恒诺康医药科技有限公司 | 2019-07-11 | — | — | WO | disclosed |