SCHEMBL21163006

SCHEMBL21163006

Cc1ccc(Oc2ccc(N=CC=O)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TEAD4 Q15561 1/20 0.44
ALDH1A1 P00352 3/20 0.42
MAPT P10636 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
POLB P06746 1/20 0.42
KDM4E B2RXH2 2/20 0.41
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
HTT P42858 3/20 0.40
MMP13 P45452 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
PTGS2 P35354 2/20 0.36
LMNA P02545 1/20 0.36
PTGS1 P23219 1/20 0.36
CA12 O43570 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13590033 0.90 ADRA2A (0.40) ALDH1A1MAPTTDP1POLBHTT
SCHEMBL21162717 0.88 TEAD4 (0.50) TEAD4ALDH1A1MAPTTDP1POLB
SCHEMBL7091916 0.88 ALDH1A1 (0.48) ALDH1A1MAPTTDP1POLBKDM4E
SCHEMBL14459430 0.79 S100B (0.49) ALDH1A1MAPTSMN1; SMN2KMT2APTGS2
SCHEMBL13590027 0.77 S100B (0.50) ALDH1A1MAPTTDP1KDM4ECYP2D6
SCHEMBL30621334 0.75 CYP2D6 (0.56) ALDH1A1MAPTTDP1KDM4ECYP2D6
SCHEMBL14816948 0.75 CYP2D6 (0.56) ALDH1A1MAPTTDP1KDM4ECYP2D6
SCHEMBL14382844 0.75 ACHE (0.62) ALDH1A1MAPTKDM4ECYP2D6CYP2C9
SCHEMBL668152 0.73 TEAD4 (0.47) TEAD4ALDH1A1MAPTTDP1POLB
SCHEMBL21163007 0.73 CYP2D6 (0.43) TEAD4ALDH1A1MAPTTDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10344115-B2 Amine glyoxal resins INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-07-09 US disclosed