Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23154100 | 0.84 | CHRNB2 (0.49) | GPR119TRPV1HRH3CHRNB2CHRNA4 | |
| SCHEMBL18997473 | 0.77 | GPR119 (0.55) | GPR119TRPV1CHRNB2CHRNA4ADAMTS5 | |
| SCHEMBL16546680 | 0.77 | HRH3 (0.55) | HRH3CHRNB2CHRNA4DRD2DRD3 | |
| SCHEMBL9557965 | 0.75 | CHRNB2 (0.59) | TRPV1CHRNB2CHRNA4 | |
| SCHEMBL1433477 | 0.75 | TRPV1 (0.54) | GPR119TRPV1HRH3CHRNB2CHRNA4 | |
| SCHEMBL30663952 | 0.75 | TRPV1 (0.54) | GPR119TRPV1HRH3CHRNB2CHRNA4 | |
| SCHEMBL19001331 | 0.74 | ADAMTS5 (0.58) | GPR119TRPV1HRH3CHRNB2CHRNA4 | |
| SCHEMBL10294018 | 0.74 | CHRNB2 (0.54) | GPR119HRH3CHRNB2CHRNA4 | |
| SCHEMBL27781454 | 0.74 | TRPV1 (0.56) | GPR119TRPV1CHRNB2CHRNA4ADAMTS5 | |
| SCHEMBL594813 | 0.74 | GPR119 (0.80) | GPR119TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019136244-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2019-07-11 | — | — | WO | disclosed |