Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | PAK4 | O96013 | 4/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | LTK | P29376 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.45 |
| ▸ | MST1R | Q04912 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14602560 | 0.91 | CA12 (0.45) | CLK2KMT2AMEN1MAPTCACNA1B | |
| SCHEMBL14602563 | 0.88 | ENPP2 (0.46) | PTK2KMT2AMEN1MAPTCACNA1B | |
| SCHEMBL14641137 | 0.86 | CA2 (0.48) | AURKAPAK4MAPK8LRRK2CLK4 | |
| SCHEMBL21163672 | 0.86 | AURKA (0.41) | AURKAPAK4MAPK8LRRK2CLK4 | |
| SCHEMBL15729868 | 0.84 | NPC1 (0.45) | KMT2AMEN1MAPTCACNA1BAPBA1 | |
| SCHEMBL14602555 | 0.83 | MEN1 (0.55) | ALKKMT2AMEN1MAPTCACNA1B | |
| SCHEMBL14384343 | 0.83 | AURKA (0.59) | AURKAPAK4MAPK8LRRK2CLK4 | |
| SCHEMBL14602564 | 0.83 | CHAT (0.44) | KDRKMT2AMEN1MAPTCACNA1B | |
| SCHEMBL2205601 | 0.81 | CA12 (0.47) | KMT2AMEN1MAPTCACNA1BAPBA1 | |
| SCHEMBL18043806 | 0.81 | CA12 (0.47) | KMT2AMEN1MAPTCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190209572-A1 | BIFUNCTIONAL ANTIFUNGAL AGENTS AND METHODS OF TREATING FUNGAL INFECTION | MERCK SHARP & DOHME CORP. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190209572-A1 | BIFUNCTIONAL ANTIFUNGAL AGENTS AND METHODS OF TREATING FUNGAL INFECTION | ERG28, PAICS, BAK1 | AURKA 150/4885PAK4 1872/4885MAPK8 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.