Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782817 | 0.91 | HPGD (0.47) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL20381018 | 0.87 | MEN1 (0.41) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18436000 | 0.84 | PIK3CD (0.44) | HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL10250795 | 0.81 | PGK1 (0.47) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL20613635 | 0.81 | NAAA (0.32) | ALDH1A1MEN1KMT2A | |
| SCHEMBL12335208 | 0.81 | MEN1 (0.35) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL2627665 | 0.80 | HPGD (0.47) | HPGDKDM4EHSD17B10SMN1; SMN2HTT | |
| SCHEMBL18272799 | 0.80 | HPGD (0.41) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL12660831 | 0.80 | HPGD (0.41) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL13690825 | 0.80 | HPGD (0.41) | HPGDKDM4EHSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | PAICS, HAVCR2, DCLRE1B | HPGD 4469/4885KDM4E 4499/4885HSD17B10 4016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.