Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | USP14 | P54578 | 2/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19749173 | 0.88 | NOTUM (0.44) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL6921452 | 0.77 | USP14 (0.56) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL18482772 | 0.76 | NOTUM (0.53) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL23559540 | 0.75 | SMN1; SMN2 (0.49) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL21479704 | 0.74 | ALDH1A1 (0.47) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL23559501 | 0.74 | SMN1; SMN2 (0.48) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL21479769 | 0.73 | SMN1; SMN2 (0.47) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL6921657 | 0.72 | NOTUM (0.65) | NOTUMSMN1; SMN2KDM4EUSP14USP7 | |
| SCHEMBL1205131 | 0.68 | AOC3 (0.72) | KDM4EAOC3 | |
| SCHEMBL18483232 | 0.68 | NOTUM (0.59) | NOTUMSMN1; SMN2KDM4EUSP14USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | NOTUM 2331/4885SMN1; SMN2 307/4885KDM4E 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.