Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.62 |
| ▸ | MET | P08581 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167444 | 0.87 | CSF1R (0.46) | CSF1RMETLDHALDHB | |
| SCHEMBL24590999 | 0.84 | MET (0.44) | CSF1RMETLDHALDHB | |
| SCHEMBL21167601 | 0.82 | CSF1R (0.40) | CSF1RMETMAPK1MKNK1LDHA | |
| SCHEMBL21167565 | 0.82 | CSF1R (0.62) | CSF1RMETMAPK1MKNK1MERTK | |
| SCHEMBL24591001 | 0.81 | CSF1R (0.58) | CSF1RMETMAPK1MKNK1FGFR1 | |
| SCHEMBL22475951 | 0.79 | CSF1R (0.58) | CSF1RMETMAPK1MKNK1FGFR1 | |
| SCHEMBL24591017 | 0.76 | MET (0.43) | CSF1RMETFGFR1FGFR2FGFR3 | |
| SCHEMBL21167443 | 0.76 | MET (0.42) | CSF1RMETMAPK1FGFR1FGFR2 | |
| SCHEMBL21167421 | 0.76 | CSF1R (0.59) | CSF1RMETMAPK1MKNK1LDHA | |
| SCHEMBL21167364 | 0.74 | CSF1R (0.60) | CSF1RMETMAPK1MKNK1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |