Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.62 |
| ▸ | MET | P08581 | 7/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167564 | 0.87 | MET (0.59) | CSF1RMETLDHALDHB | |
| SCHEMBL21167473 | 0.86 | MET (0.47) | CSF1RMETLDHALDHB | |
| SCHEMBL12487188 | 0.85 | MET (0.54) | CSF1RMETMKNK1IRAK1IRAK4 | |
| SCHEMBL22475951 | 0.85 | CSF1R (0.58) | CSF1RMETLDHALDHBMKNK1 | |
| SCHEMBL24591021 | 0.84 | MET (0.44) | CSF1RMETLDHALDHB | |
| SCHEMBL21167754 | 0.84 | MET (0.60) | CSF1RMETLDHALDHB | |
| SCHEMBL21167667 | 0.84 | LDHA (0.44) | CSF1RMETLDHALDHBMKNK1 | |
| SCHEMBL21167604 | 0.82 | CSF1R (0.62) | CSF1RMETLDHALDHBMKNK1 | |
| SCHEMBL21167751 | 0.82 | LDHA (0.43) | CSF1RMETLDHALDHBMKNK1 | |
| SCHEMBL21167458 | 0.80 | LDHA (0.43) | CSF1RMETLDHALDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |