Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167697 | 0.82 | MTNR1A (0.44) | MTNR1ACYP3A4MAP4K1SYKTDO2 | |
| SCHEMBL22475688 | 0.78 | HDAC3 (0.42) | SYKUSP7 | |
| SCHEMBL24591093 | 0.77 | FGFR1 (0.53) | CYP3A4NTRK1SYKGPR84PDPK1 | |
| SCHEMBL21167574 | 0.76 | MET (0.55) | CYP3A4MAP4K1GPR84CDK2 | |
| SCHEMBL21167797 | 0.74 | MET (0.43) | CYP3A4MAP4K1PDPK1CDC7ROCK2 | |
| SCHEMBL16882543 | 0.73 | MTNR1A (0.42) | MTNR1ACYP3A4SYKTDO2GPR84 | |
| SCHEMBL12487535 | 0.73 | MET (0.48) | MTNR1ASYKTDO2GPR84DYRK1A | |
| SCHEMBL22475864 | 0.72 | GPR84 (0.43) | MTNR1ACYP3A4MAP4K1SYKGPR84 | |
| SCHEMBL21167357 | 0.72 | MET (0.47) | PDPK1 | |
| SCHEMBL23127946 | 0.67 | BCHE (0.34) | NTRK1GPR84PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |