Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475864 | 0.90 | GPR84 (0.43) | MTNR1ACYP3A4MAP4K1SYKCYP2C19 | |
| SCHEMBL21167698 | 0.82 | MTNR1A (0.42) | MTNR1ACYP3A4MAP4K1SYKTDO2 | |
| SCHEMBL21167798 | 0.76 | FGFR1 (0.54) | CYP3A4SYKCYP2C19KIT | |
| SCHEMBL12487535 | 0.75 | MET (0.48) | MTNR1ASYKTDO2GPR84 | |
| SCHEMBL16882543 | 0.75 | MTNR1A (0.42) | MTNR1ACYP3A4SYKTDO2GPR84 | |
| SCHEMBL22475696 | 0.73 | MET (0.44) | CYP3A4SYKCYP2C19GPR84 | |
| SCHEMBL22475837 | 0.71 | MAP4K3 (0.49) | PDPK1 | |
| SCHEMBL21167387 | 0.67 | SYK (0.48) | SYK | |
| SCHEMBL21167358 | 0.67 | GPR84 (0.37) | CYP3A4CYP2C19GPR84PDPK1 | |
| SCHEMBL2197248 | 0.67 | GPR84 (0.50) | MTNR1ACYP3A4CYP2C19CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |