Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | LDHB | P07195 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 5/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167667 | 0.84 | LDHA (0.44) | LDHALDHBCSF1RMETMKNK1 | |
| SCHEMBL21167601 | 0.82 | CSF1R (0.40) | LDHALDHBCSF1RMETCCNK | |
| SCHEMBL21167565 | 0.82 | CSF1R (0.62) | LDHALDHBCSF1RMETMAPK1 | |
| SCHEMBL21167458 | 0.80 | LDHA (0.43) | LDHALDHBCSF1RMETPIK3CD | |
| SCHEMBL21167831 | 0.80 | LDHA (0.38) | LDHALDHBCSF1RMETPIK3CD | |
| SCHEMBL21167564 | 0.79 | MET (0.59) | LDHALDHBCSF1RMETIKBKE | |
| SCHEMBL21167473 | 0.79 | MET (0.47) | LDHALDHBCSF1RMETPIK3CD | |
| SCHEMBL24591021 | 0.78 | MET (0.44) | LDHALDHBCSF1RMETPIK3CD | |
| SCHEMBL21167754 | 0.78 | MET (0.60) | LDHALDHBCSF1RMETPIK3CD | |
| SCHEMBL31030392 | 0.71 | SCN5A (0.51) | AKT1AKT2PIK3CDROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |