Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.44 |
| ▸ | USP2 | O75604 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591093 | 0.81 | FGFR1 (0.53) | FGFR1FGFR4SYKCYP3A4CYP2C19 | |
| SCHEMBL22475864 | 0.80 | GPR84 (0.43) | FGFR1FGFR4SYKCYP3A4CYP2C19 | |
| SCHEMBL21167708 | 0.78 | SYK (0.53) | SYKCYP3A4CYP2C19USP2CYP1A2 | |
| SCHEMBL22475696 | 0.78 | MET (0.44) | SYKCYP3A4CYP2C19CDC7ROCK2 | |
| SCHEMBL21167697 | 0.76 | MTNR1A (0.44) | SYKCYP3A4CYP2C19KIT | |
| SCHEMBL16882541 | 0.74 | FGFR1 (0.53) | FGFR1FGFR4SYKCYP3A4CYP1A2 | |
| SCHEMBL12693327 | 0.74 | FGFR1 (0.53) | FGFR1FGFR4SYKDRD4DRD3 | |
| SCHEMBL857087 | 0.72 | CDC7 (0.64) | FGFR1FGFR4CLK4DYRK1AKIT | |
| SCHEMBL22475837 | 0.72 | MAP4K3 (0.49) | PAK4PIM1 | |
| SCHEMBL857805 | 0.71 | FGFR1 (1.00) | FGFR1FGFR4CYP3A4CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |