Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475874 | 0.90 | MET (0.46) | METHDAC1SYKADORA2AHDAC3 | |
| SCHEMBL21167638 | 0.87 | SYK (0.46) | METSYKHDAC3NPC1KDR | |
| SCHEMBL21167474 | 0.86 | SYK (0.48) | METHDAC1SYKHDAC3NPC1 | |
| SCHEMBL21167803 | 0.86 | MET (0.45) | METHDAC1SYKADORA2AKCNA5 | |
| SCHEMBL21167387 | 0.83 | SYK (0.48) | METSYKHDAC3NPC1KDR | |
| SCHEMBL22754358 | 0.81 | SYK (0.47) | METSYKHDAC3NPC1KDR | |
| SCHEMBL21167571 | 0.80 | PIK3CD (0.43) | METHDAC1SYKHDAC3NPC1 | |
| SCHEMBL21167394 | 0.80 | SYK (0.39) | METSYKHDAC3NPC1KDR | |
| SCHEMBL24591018 | 0.79 | MET (0.50) | METSYKHDAC3NPC1KDR | |
| SCHEMBL22754381 | 0.79 | SYK (0.47) | METSYKHDAC3NPC1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |