Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120200 | 0.81 | ACLY (0.48) | HSD11B1SGK1MYCKAT6ACCR2 | |
| SCHEMBL2118331 | 0.79 | HSD11B1 (0.62) | HSD11B1IDO1TP53THRBDRD2 | |
| SCHEMBL2117206 | 0.77 | SYK (0.46) | SYKSGK1TP53THRBKAT6A | |
| SCHEMBL2117286 | 0.76 | SYK (0.48) | SYKSGK1TP53KAT6ACCR2 | |
| SCHEMBL2117837 | 0.74 | STAT3 (0.60) | HSD11B1IDO1ALPLDRD2HTR2A | |
| SCHEMBL2119847 | 0.70 | CCR2 (0.41) | HSD11B1SGK1MYCTP53THRB | |
| SCHEMBL2118454 | 0.70 | HSD11B1 (0.51) | HSD11B1TP53THRBALPLDRD2 | |
| SCHEMBL23873781 | 0.69 | CYP2A6 (0.58) | HSD11B1KCNH2SCN10A | |
| SCHEMBL29059425 | 0.67 | CCR2 (0.49) | SYKSGK1CCR2ACLY | |
| SCHEMBL2120543 | 0.66 | KAT6A (0.53) | TP53KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| EP-2382190-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | European Molecular Biology Laboratory (EMBL) (DE) | 2011-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1A, HIF1AN, EGLN3 | SYK 393/4885HSD11B1 3376/4885SGK1 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.