Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 9/20 | 0.40 |
| ▸ | LTA4H | P09960 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21168334 | 1.00 | MME (0.40) | MMEMMEL1ACELTA4HF2 | |
| SCHEMBL25476871 | 0.94 | F2 (0.39) | MMEMMEL1ACEF2PLG | |
| SCHEMBL21168491 | 0.93 | FKBP1A (0.41) | ACEF2FKBP1A | |
| SCHEMBL21168289 | 0.91 | FABP4 (0.32) | MMEMMEL1FKBP1A | |
| SCHEMBL21168290 | 0.91 | FABP4 (0.32) | MMEMMEL1FKBP1A | |
| SCHEMBL23351265 | 0.89 | FABP4 (0.32) | MMEMMEL1ACEFKBP1A | |
| SCHEMBL21168342 | 0.88 | VSIR (0.35) | MMEMMEL1ACELTA4HFKBP1A | |
| SCHEMBL21168352 | 0.88 | VSIR (0.35) | MMEMMEL1ACELTA4HFKBP1A | |
| SCHEMBL21168362 | 0.88 | ACE (0.33) | MMEMMEL1ACEFKBP1A | |
| SCHEMBL21168340 | 0.88 | ACE (0.33) | MMEMMEL1ACEFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144653-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling Pathways | AURIGENE ONCOLOGY LIMITED (IN) | 2023-05-11 | — | — | US | disclosed |
| US-20230144653-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling Pathways | AURIGENE ONCOLOGY LIMITED (IN) | 2023-05-11 | — | — | US | disclosed |
| US-11560403-B2 | 1,2,4-oxadiazole compounds as inhibitors of CD47 signaling pathways | AURIGENE ONCOLOGY LIMITED (IN) | 2023-01-24 | — | — | US | disclosed |
| US-20210139536-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling Pathways | AURIGENE ONCOLOGY LIMITED (IN) | 2021-05-13 | — | — | US | disclosed |
| US-20190218252-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11560403-B2 | 1,2,4-oxadiazole compounds as inhibitors of CD47 signaling pathways | CD47, HIF1AN, PIK3R5 | MME 4839/4885MMEL1 2202/4885ACE 4818/4885 |
| US-20230144653-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling Pathways | CD47, HIF1AN, PIK3R5 | MME 4851/4885MMEL1 2379/4885ACE 4811/4885 |
| US-20210139536-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling Pathways | CD47, HIF1AN, PIK3R5 | MME 4851/4885MMEL1 2379/4885ACE 4811/4885 |
| US-20190218252-A1 | 1,2,4-Oxadiazole Compounds as Inhibitors of CD47 Signalling | CD47, HIF1AN, PIK3R5 | MME 4850/4885MMEL1 2263/4885ACE 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.