Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287289 | 0.89 | DPP4 (0.42) | TRPM8FYNALDH1A1RAB9AMEN1 | |
| SCHEMBL12287723 | 0.89 | DPP4 (0.42) | TRPM8FYNALDH1A1RAB9AMEN1 | |
| SCHEMBL21170038 | 0.89 | DPP4 (0.42) | TRPM8FYNALDH1A1RAB9AMEN1 | |
| SCHEMBL21170174 | 0.88 | GPR52 (0.42) | MAP4K4FYNABL1BCRRIPK1 | |
| SCHEMBL21170185 | 0.88 | TRPM8 (0.41) | MAPTTP53THRBTRPM8ALDH1A1 | |
| SCHEMBL21170152 | 0.88 | RIPK1 (0.41) | ALDH1A1RIPK1 | |
| SCHEMBL21170310 | 0.87 | ADORA1 (0.41) | MAPTTP53THRBALDH1A1KMT2A | |
| SCHEMBL21170046 | 0.86 | RIPK1 (0.40) | ABL1BCRRIPK1 | |
| SCHEMBL21170326 | 0.83 | TRPV3 (0.49) | MAPTTP53ALDH1A1RAB9AMEN1 | |
| SCHEMBL21170090 | 0.82 | NPY5R (0.39) | TRPM8FYNALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |