Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170217 | 0.86 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170452 | 0.84 | PPM1D (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170042 | 0.80 | PARP1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12287887 | 0.80 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170054 | 0.80 | ROCK2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170460 | 0.78 | AKT1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170243 | 0.77 | MAPK1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170135 | 0.77 | MAPK1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170220 | 0.77 | FAAH (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22191096 | 0.76 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |