Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286737 | 0.82 | MTOR (0.39) | AKT1PIK3CAMTORLMNARAB9A | |
| SCHEMBL21170458 | 0.81 | MAPK1 (0.43) | AKT1RAB9AMAPK1KDRMAPK13 | |
| SCHEMBL21170240 | 0.81 | ADORA3 (0.34) | LMNARAB9AADORA3ADORA2AMAPK14 | |
| SCHEMBL21170335 | 0.79 | EP300 (0.45) | RAB9AADORA3ADORA2AMAPK14TDO2 | |
| SCHEMBL21170087 | 0.78 | PSEN1 (0.41) | LMNARAB9ANPC1MAPK14KDM4E | |
| SCHEMBL14734752 | 0.76 | AKT1 (0.45) | AKT1PIK3CAMTORLMNARAB9A | |
| SCHEMBL21170452 | 0.75 | PPM1D (0.48) | AKT1RAB9ANPC1MAPK14PSEN1 | |
| SCHEMBL21170217 | 0.75 | PSEN1 (0.36) | RAB9ANPC1MAPK14PSEN1PSEN2 | |
| SCHEMBL21170220 | 0.75 | FAAH (0.43) | RAB9ANPC1MAPK14TP53MET | |
| SCHEMBL21170453 | 0.74 | NTRK1 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |