Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170135 | 0.85 | MAPK1 (0.38) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170338 | 0.84 | PSEN1 (0.39) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170049 | 0.83 | DYRK1A (0.38) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170454 | 0.83 | CCNT1 (0.36) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170453 | 0.83 | NTRK1 (0.44) | MAPK1NTRK1DYRK1A | |
| SCHEMBL21170450 | 0.82 | CDC7 (0.38) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170458 | 0.82 | MAPK1 (0.43) | MAPK1RAB9ANTRK1CDK9PIM1 | |
| SCHEMBL12290009 | 0.81 | PSEN1 (0.35) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170346 | 0.81 | MAPK1 (0.48) | MAPK1NTRK1CDK9PIM1DYRK1A | |
| SCHEMBL21170217 | 0.80 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |