Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 2/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565340 | 0.90 | MKNK2 (0.48) | MKNK2MKNK1BDKRB1 | |
| SCHEMBL21170321 | 0.87 | NPC1 (0.33) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL2566237 | 0.80 | TRPV3 (0.45) | MKNK2NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL12289914 | 0.79 | HPGD (0.45) | NPC1RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL12288241 | 0.79 | NPC1 (0.48) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL2561290 | 0.78 | FPR2 (0.40) | NPC1RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL21170414 | 0.78 | FGFR3 (0.36) | NPC1RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL12286731 | 0.78 | VNN1 (0.41) | NPC1RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL12287836 | 0.78 | ACSS2 (0.41) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL12287801 | 0.77 | CRBN (0.45) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |