Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | SNCA | P37840 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004447 | 0.78 | SNCA (0.70) | GRM5SNCAMAPTGRM4CDK2 | |
| SCHEMBL14629344 | 0.74 | CDK5 (0.35) | — | |
| SCHEMBL21170732 | 0.73 | PRMT5 (0.46) | GRM5SNCAMAPTGRM4APP | |
| SCHEMBL180217 | 0.71 | CCNB2 (0.50) | — | |
| SCHEMBL20004279 | 0.70 | SNCA (0.68) | SNCAMAPTAPP | |
| SCHEMBL5353844 | 0.68 | APP (0.46) | SNCAMAPTAPP | |
| SCHEMBL20004547 | 0.68 | MAPT (0.58) | SNCAMAPT | |
| SCHEMBL20005009 | 0.67 | SNCA (0.64) | SNCAMAPT | |
| SCHEMBL22537701 | 0.67 | SNCA (0.56) | GRM5SNCAMAPT | |
| SCHEMBL20005138 | 0.67 | SNCA (0.72) | SNCAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |