Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19583404 | 0.80 | CYP4F2 (0.32) | ERN1 | |
| SCHEMBL346730 | 0.78 | CYP11B2 (0.54) | ERN1CYP11B1CYP11B2PTGS2LMNA | |
| SCHEMBL19600976 | 0.74 | MIF (0.40) | CYP19A1 | |
| SCHEMBL29720433 | 0.74 | MIF (0.40) | CYP19A1 | |
| SCHEMBL9165973 | 0.72 | MAOA (0.51) | CA2 | |
| SCHEMBL10071548 | 0.71 | RXRB (0.41) | PTGS2LMNATP53NAMPTCA2 | |
| SCHEMBL9220414 | 0.71 | S1PR1 (0.40) | CYP11B1CYP11B2CA2 | |
| SCHEMBL1589975 | 0.70 | ALDH1A1 (0.44) | PTGS2 | |
| SCHEMBL19583406 | 0.69 | ADRA1A (0.32) | — | |
| SCHEMBL1868779 | 0.68 | S1PR1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094943-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| EP-1891036-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | University of Florida Research Foundation, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133303-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094943-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | CHRNA7, CHRNA10, CHRNA5 | ERN1 3898/4885CYP11B1 1648/4885CYP11B2 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.