Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSGALNACT1 | Q8TDX6 | 2/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.49 |
| ▸ | TSPO | P30536 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11619922 | 0.87 | PTPN1 (0.57) | PTPN1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3101558 | 0.82 | PTPN1 (0.64) | CSGALNACT1PTPN1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20303187 | 0.80 | HDAC4 (0.55) | PTPN1 | |
| SCHEMBL15919682 | 0.80 | PTPN1 (0.56) | PTPN1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3533246 | 0.80 | SMN1; SMN2 (0.51) | USP30PTPN1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL212382 | 0.80 | RAB9A (0.68) | CYP2C9PTPN1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8183194 | 0.80 | ABCB1 (0.55) | P2RY14TSPOCYP2C9TMEM97SIGMAR1 | |
| SCHEMBL5202132 | 0.80 | ABCB1 (0.55) | P2RY14TSPOCYP2C9TMEM97SIGMAR1 | |
| SCHEMBL2117865 | 0.79 | KDM4E (0.52) | CSGALNACT1USP30CYP2C9SMN1; SMN2ALDH1A1 | |
| SCHEMBL8880032 | 0.79 | HCAR2 (0.55) | CSGALNACT1PTPN1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102781915-A | Diacylglycerol acyltransferase inhibitors | PIRAMAL LIFE SCIENCES LTD | 2012-11-14 | — | — | CN | disclosed |
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | CSGALNACT1 858/4885USP30 3311/4885P2RY14 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.