Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.41 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434768 | 0.85 | MAPT (0.46) | KMT2AMAPTMEN1S1PR4LMNA | |
| SCHEMBL277081 | 0.84 | SMN1; SMN2 (0.48) | MAPTLMNAGAATDP1ALDH1A1 | |
| SCHEMBL2858714 | 0.84 | MAPT (0.49) | KMT2AMAPTMEN1LMNAMAPK1 | |
| SCHEMBL1741190 | 0.84 | ALDH1A1 (0.53) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL2200457 | 0.84 | CHRNA1 (0.47) | MAPTLMNAMAPK1NPSR1KDM4E | |
| SCHEMBL4800700 | 0.83 | SMN1; SMN2 (0.47) | MAPTLMNAGAATDP1ALDH1A1 | |
| SCHEMBL2853000 | 0.83 | KMT2A (0.48) | KMT2AMAPTMEN1S1PR4LMNA | |
| SCHEMBL2852255 | 0.83 | HDAC3 (0.48) | MAPTLMNATDP1ALDH1A1SLC6A2 | |
| SCHEMBL14346527 | 0.82 | CA12 (0.36) | KMT2AMAPTMEN1LMNAGAA | |
| SCHEMBL16883572 | 0.81 | KMT2A (0.43) | KMT2AMAPTMEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410097-B2 | Heteropyrrole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410097-B2 | Heteropyrrole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410097-B2 | Heteropyrrole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2013-04-02 | — | — | US | disclosed |
| US-8354442-B2 | Imidazol-4-one and imidazole-4-thione compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-01-15 | — | — | US | disclosed |
| US-20120095047-A1 | Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors | UNIVERSITY OF CONNECTICUT (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095047-A1 | Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors | UNIVERSITY OF CONNECTICUT (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095047-A1 | Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors | UNIVERSITY OF CONNECTICUT (US) | 2012-04-19 | — | — | US | disclosed |
| US-8084467-B2 | For both CB1 and CB2 receptor sites; 3-(N-hetero)amido-5-phenyl pyrazoles; memory deficits associated with aging or nervous system disorders, obesity, schizophrenia, septic shock | UNIVERSITY OF CONNECTICUT (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084467-B2 | For both CB1 and CB2 receptor sites; 3-(N-hetero)amido-5-phenyl pyrazoles; memory deficits associated with aging or nervous system disorders, obesity, schizophrenia, septic shock | UNIVERSITY OF CONNECTICUT (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084467-B2 | For both CB1 and CB2 receptor sites; 3-(N-hetero)amido-5-phenyl pyrazoles; memory deficits associated with aging or nervous system disorders, obesity, schizophrenia, septic shock | UNIVERSITY OF CONNECTICUT (US) | 2011-12-27 | — | — | US | disclosed |
| US-7393842-B2 | Pyrazole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1845972-A2 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINIOD RECEPTORS | University of Connecticut (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074445-A2 | NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINIOD RECEPTORS | MAKRIYANNIS ALEXANDROS (US) | 2006-07-13 | — | — | WO | disclosed |
| US-20060100208-A1 | Pyrazole derivatives as cannabinoid receptor antagonists | UNIVERSITY OF CONNECTICUT | 2006-05-11 | — | — | US | disclosed |
| US-20060030563-A1 | Novel pyrazole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT | 2006-02-09 | — | — | US | disclosed |
| EP-1571147-A2 | Pyrazole analogs acting on cannabinoid receptors | The University of Connecticut (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1421077-A4 | NOVEL PYRAZOLE ANALOGS ACTING ON CANNABINOID RECEPTORS | UNIV CONNECTICUT (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20040192667-A1 | Novel pyrazole analogs acting on cannabinoid receptors | UNIVERSITY OF CONNECTICUT | 2004-09-30 | — | — | US | disclosed |
| EP-1421077-A2 | NOVEL PYRAZOLE ANALOGS ACTING ON CANNABINOID RECEPTORS | THE UNIVERSITY OF CONNECTICUT (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003020217-A2 | NOVEL PYRAZOLE ANALOGS ACTING ON CANNABINOID RECEPTORS | UNIVERSITY OF CONNECTICUT (US) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192667-A1 | Novel pyrazole analogs acting on cannabinoid receptors | CNR1, CNR2, P2RY1 | KMT2A 3405/4885MAPT 2878/4885MEN1 3423/4885 |
| US-20120095047-A1 | Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors | CNR2, CNR1, GPR18 | KMT2A 4192/4885MAPT 4082/4885MEN1 4465/4885 |
| US-20060030563-A1 | Novel pyrazole analogs acting on cannabinoid receptors | CNR1, CNR2, P2RY1 | KMT2A 3405/4885MAPT 2878/4885MEN1 3423/4885 |
| US-20060100208-A1 | Pyrazole derivatives as cannabinoid receptor antagonists | CNR1, CNR2, P2RY1 | KMT2A 3566/4885MAPT 3162/4885MEN1 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.