Sugi Predict

Sugi Predict / Compounds / SCHEMBL21177259

SCHEMBL21177259

SCHEMBL21177259

O=C(O)c1nn(C2CCOCC2)cc(-c2ccc(F)cc2)c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IRAK4 Q9NWZ3 3/20 0.48
▸ MET P08581 2/20 0.40
▸ AXL P30530 2/20 0.40
▸ HDAC1 Q13547 2/20 0.39
▸ HDAC2 Q92769 2/20 0.39
▸ CSNK1D P48730 6/20 0.39
▸ CSNK1E P49674 6/20 0.39
▸ PRKAB2 O43741 1/20 0.39
▸ PRKAG1 P54619 1/20 0.39
▸ PRKAA2 P54646 1/20 0.39
▸ PRKAA1 Q13131 1/20 0.39
▸ PRKAG3 Q9UGI9 1/20 0.39
▸ PRKAG2 Q9UGJ0 1/20 0.39
▸ PRKAB1 Q9Y478 1/20 0.39
▸ KDM4C Q9H3R0 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ BRAF P15056 1/20 0.36
▸ MAPK3 P27361 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21753543 0.92 CSNK1D (0.44) IRAK4CSNK1DCSNK1EALDH1A1
SCHEMBL21176835 0.88 CFTR (0.40) IRAK4AXLALDH1A1BRAFMAPK3
SCHEMBL21176856 0.84 IRAK4 (0.43) IRAK4METAXLALDH1A1
SCHEMBL21185782 0.82 IRAK4 (0.41) IRAK4METAXLHDAC1HDAC2
SCHEMBL29902513 0.82 IRAK4 (0.47) IRAK4CSNK1DCSNK1E
SCHEMBL25037802 0.81 AXL (0.43) METAXLHDAC1HDAC2PRKAB2
SCHEMBL21753560 0.79 DRD2 (0.38) CSNK1DCSNK1EALDH1A1CFTR
SCHEMBL29576306 0.79 IRAK4 (0.47) IRAK4AXLJAK1
SCHEMBL25035781 0.77 SCD (0.40) IRAK4METAXLJAK1
SCHEMBL20351563 0.76 MET (0.53) IRAK4METAXLHDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110041316-B TAM family kinase/CSF 1R kinase inhibitors and uses thereof 药捷安康(南京)科技股份有限公司 2022-04-19 — — CN disclosed
US-20210177828-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2021-06-17 — — US disclosed
US-20210177828-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2021-06-17 — — US disclosed
EP-3741752-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF Nanjing Transthera Biosciences Co., Ltd. (CN) 2020-11-25 — — EP disclosed
EP-3741752-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF Nanjing Transthera Biosciences Co., Ltd. (CN) 2020-11-25 — — EP disclosed
WO-2019141202-A9 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF 南京药捷安康生物科技有限公司 2019-08-29 — — WO disclosed
WO-2019141202-A9 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF 南京药捷安康生物科技有限公司 2019-08-29 — — WO disclosed
WO-2019141202-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF 南京药捷安康生物科技有限公司 2019-07-25 — — WO disclosed
WO-2019141202-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF 南京药捷安康生物科技有限公司 2019-07-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210177828-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF CSF1R, CSF3R, FLT3 IRAK4 69/4885MET 107/4885AXL 68/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.