Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.44 |
| ▸ | KYNU | Q16719 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115818 | 0.80 | KYNU (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2116612 | 0.78 | MAPT (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3425983 | 0.75 | MAPT (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2118060 | 0.73 | CA1 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2861260 | 0.72 | ALDH1A1 (0.56) | CTSLCTSSCTSBALDH1A1ALOX15 | |
| SCHEMBL2419128 | 0.72 | ALDH1A1 (0.56) | CTSLCTSSCTSBALDH1A1ALOX15 | |
| SCHEMBL24130582 | 0.71 | KYNU (0.62) | KYNUCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL24130581 | 0.71 | KYNU (0.62) | KYNUCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL2936831 | 0.70 | KYNU (0.57) | KYNUCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL27845832 | 0.70 | KYNU (0.57) | KYNUCTSLCTSSCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2012-04-19 | — | — | US | disclosed |
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | FDPS, GGPS1, CTPS1 | HDAC3 4127/4885HDAC4 3989/4885HDAC1 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.