SCHEMBL21177858

SCHEMBL21177858

COc1ccc([S+]([O-])C/[C]=C\Cc2ccc(F)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
TP53 P04637 1/20 0.40
CYP3A4 P08684 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
ALOX12 P18054 1/20 0.40
NFE2L2 Q16236 1/20 0.40
FPR2 P25090 1/20 0.36
EGFR P00533 1/20 0.36
ERBB2 P04626 1/20 0.36
MAPK1 P28482 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
ATM Q13315 2/20 0.35
MAOB P27338 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21177725 1.00 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177863 0.87 SMN1; SMN2 (0.40) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177862 0.87 SMN1; SMN2 (0.40) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177737 0.86 LTA4H (0.42) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177855 0.86 LTA4H (0.42) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177551 0.86 LTA4H (0.42) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL21177845 0.85 MAOB (0.45) SMN1; SMN2CYP3A4NFE2L2MEN1KMT2A
SCHEMBL21182299 0.85 MAOB (0.45) SMN1; SMN2CYP3A4NFE2L2MEN1KMT2A
SCHEMBL21177879 0.82 PLAAT3 (0.32) ALDH1A1NFE2L2KMT2AKDM4E
SCHEMBL21177912 0.82 PLAAT3 (0.32) ALDH1A1NFE2L2KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019143143-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEUROBLASTOMA OR RHEUMATOID ARTHRITIS 숙명여자대학교 산학협력단 2019-07-25 WO claimed
WO-2019143142-A1 NOVEL PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING GLIOBLASTOMA 숙명여자대학교 산학협력단 2019-07-25 WO claimed
WO-2019143143-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEUROBLASTOMA OR RHEUMATOID ARTHRITIS 숙명여자대학교 산학협력단 2019-07-25 WO disclosed
WO-2019143142-A1 NOVEL PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING GLIOBLASTOMA 숙명여자대학교 산학협력단 2019-07-25 WO disclosed