Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | DCK | P27707 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177698 | 0.88 | GPR119 (0.40) | PDE10AGPR6TBK1IKBKERET | |
| SCHEMBL21191757 | 0.87 | PDE10A (0.44) | PDE10AGPR6CHEK1CHEK2KDR | |
| SCHEMBL21191758 | 0.85 | PDE10A (0.43) | PDE10AGPR6CHEK1CHEK2KDR | |
| SCHEMBL21177314 | 0.85 | PDE10A (0.43) | PDE10AGPR6CHEK1CHEK2KDR | |
| Hydrochloric Acid SCHEMBL21177938 | 0.84 | PDE10A (0.42) | PDE10AGPR6CHEK1CHEK2KDR | |
| SCHEMBL21177705 | 0.79 | PDE10A (0.42) | PDE10AGPR6RETDCKCHRM4 | |
| SCHEMBL21191756 | 0.79 | PDE10A (0.42) | PDE10AGPR6RETDCKCHRM4 | |
| SCHEMBL21179336 | 0.76 | PDE10A (0.41) | PDE10AGPR6ACACBRETDCK | |
| SCHEMBL21179334 | 0.74 | GPR6 (0.41) | GPR6TBK1JAK2HCRTR1HCRTR2 | |
| SCHEMBL21179390 | 0.74 | GPR6 (0.41) | GPR6TBK1JAK2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141957-A1 | N-PYRIMIDINYL HYDROXY PYRAZOLE DERIVATIVES AND USES THEREOF | CADO BIOTECHNOLOGY IVS (DK) | 2019-07-25 | — | — | WO | disclosed |