Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | MASTL | Q96GX5 | 2/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178859 | 0.74 | BRD4 (0.41) | AXLIDH1 | |
| SCHEMBL21179056 | 0.69 | AXL (0.36) | AXL | |
| SCHEMBL29605205 | 0.67 | ADORA2A (0.50) | AXL | |
| SCHEMBL14635390 | 0.67 | ADORA2A (0.50) | AXL | |
| SCHEMBL28634050 | 0.66 | AXL (0.52) | AXLCDK2 | |
| SCHEMBL21178314 | 0.65 | ACHE (0.40) | AXL | |
| SCHEMBL21178708 | 0.65 | L3MBTL1 (0.37) | AXL | |
| SCHEMBL21178483 | 0.65 | AXL (0.37) | AXL | |
| SCHEMBL21188515 | 0.65 | AXL (0.37) | AXLCDK2 | |
| SCHEMBL21178901 | 0.64 | AXL (0.36) | AXLCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |