Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29605205 | 0.71 | ADORA2A (0.50) | AXLADORA2AADORA1MEN1KMT2A | |
| SCHEMBL14635390 | 0.71 | ADORA2A (0.50) | AXLADORA2AADORA1MEN1KMT2A | |
| SCHEMBL28634050 | 0.70 | AXL (0.52) | AXLADORA2AADORA1CCNT1CCNA2 | |
| SCHEMBL21178314 | 0.69 | ACHE (0.40) | AXLADORA2AADORA1 | |
| SCHEMBL21178708 | 0.69 | L3MBTL1 (0.37) | AXL | |
| SCHEMBL21178483 | 0.69 | AXL (0.37) | AXL | |
| SCHEMBL21178417 | 0.68 | CCNT1 (0.42) | AXLCCNT1CDK2CDK9MEN1 | |
| SCHEMBL21178901 | 0.68 | AXL (0.36) | AXLCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL9695804 | 0.66 | ADORA2A (0.55) | ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL21178486 | 0.65 | AXL (0.36) | AXLCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |