Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | TK2 | O00142 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.37 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178589 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2PLA2G1BATG4BMAPT | |
| SCHEMBL22801209 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2PLA2G1BATG4BMAPT | |
| SCHEMBL22801262 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2PLA2G1BATG4BMAPT | |
| SCHEMBL21178038 | 0.99 | LMNA (0.45) | LMNASMN1; SMN2PLA2G1BATG4BMAPT | |
| SCHEMBL22801236 | 0.93 | LMNA (0.47) | LMNASMN1; SMN2MAPTESR1TK2 | |
| SCHEMBL22801221 | 0.90 | LMNA (0.43) | LMNASMN1; SMN2MAPTESR1TK1 | |
| SCHEMBL22589438 | 0.90 | TK1 (0.48) | TK2TK1DHFR | |
| SCHEMBL22801182 | 0.88 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2PLA2G1BATG4BMAPT | |
| SCHEMBL22801218 | 0.86 | LMNA (0.43) | LMNASMN1; SMN2MAPTESR1TK2 | |
| SCHEMBL21178133 | 0.84 | LMNA (0.45) | LMNASMN1; SMN2MAPTESR1TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427550-B2 | 5-fluorouracil compounds | NUCORION PHARMACEUTICALS, INC. (US) | 2022-08-30 | — | — | US | disclosed |
| US-20200399227-A1 | 5-FLUOROURACIL COMPOUNDS | NUCORION PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
| WO-2019143860-A1 | 5-FLUOROURACIL COMPOUNDS | NUCORION PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399227-A1 | 5-FLUOROURACIL COMPOUNDS | DPYD, DHFR, FAU | LMNA 1225/4885SMN1; SMN2 1144/4885PLA2G1B 2356/4885 |
| US-11427550-B2 | 5-fluorouracil compounds | DPYD, DHFR, MTHFD1 | LMNA 1038/4885SMN1; SMN2 1251/4885PLA2G1B 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.