Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 4/20 | 0.46 |
| ▸ | GABRD | O14764 | 4/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.46 |
| ▸ | GABRE | P78334 | 4/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6737816 | 0.79 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6649529 | 0.77 | LMNA (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1037667 | 0.75 | LMNA (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18520706 | 0.75 | LMNA (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28520292 | 0.75 | LMNA (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18825349 | 0.75 | LMNA (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL819619 | 0.75 | TSHR (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL937318 | 0.75 | LMNA (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL937050 | 0.75 | LMNA (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4361154 | 0.75 | LMNA (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2884976-B1 | 3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-07-24 | — | — | EP | disclosed |