Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.35 |
| ▸ | CCNK | O75909 | 9/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.35 |
| ▸ | CDK2 | P24941 | 8/20 | 0.35 |
| ▸ | CDK9 | P50750 | 8/20 | 0.35 |
| ▸ | CDK7 | P50613 | 7/20 | 0.35 |
| ▸ | CCNH | P51946 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184570 | 0.63 | CDK7 (0.34) | ADORA1CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL20412352 | 0.60 | PTPN11 (0.43) | FLT3ADORA1CCNKCDK12CCNT1 | |
| SCHEMBL19600354 | 0.60 | CDK7 (0.38) | FLT3TYRO3MERTKADORA1CCNK | |
| SCHEMBL9704728 | 0.59 | PDE4A (0.43) | FLT3TYRO3MERTKGAS6CDK2 | |
| SCHEMBL18069760 | 0.59 | CDK7 (0.42) | FLT3TYRO3MERTKADORA1CCNT1 | |
| SCHEMBL9704732 | 0.59 | PAK1 (0.53) | FLT3TYRO3MERTKGAS6PRKAB2 | |
| SCHEMBL16691171 | 0.59 | KDM4E (0.51) | FLT3TYRO3MERTKGAS6ADORA1 | |
| SCHEMBL5381974 | 0.58 | TLR8 (0.42) | — | |
| SCHEMBL13801653 | 0.57 | PDE4A (0.41) | — | |
| SCHEMBL20155193 | 0.57 | PAK1 (0.39) | ADORA1CDK2CDK9CDK7CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |